|
Heart Diseases
|
0.320 |
Therapeutic
|
group |
CTD_human |
Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity.
|
18948619 |
2008 |
|
Heart Diseases
|
0.320 |
Biomarker
|
group |
BEFREE |
This mini-review highlights exciting findings in animal models and human patients, with special emphasis on the potential salutary effects of Hsp20 in heart disease.
|
20869365 |
2011 |
|
Heart Diseases
|
0.320 |
GeneticVariation
|
group |
BEFREE |
We identified a C59T substitution in the human Hsp20 gene in one patient and three individuals without heart disease.
|
18790732 |
2008 |
|
Drug toxicity
|
0.300 |
Therapeutic
|
group |
CTD_human |
Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity.
|
18948619 |
2008 |
|
Adverse reaction to drug
|
0.300 |
Therapeutic
|
group |
CTD_human |
Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity.
|
18948619 |
2008 |
|
Cardiomyopathy, Dilated
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We identified a human mutant of HSPB6 (HSPB6<sup>S10F</sup>) exclusively present in dilated cardiomyopathy (DCM) patients.
|
29157081 |
2018 |
|
Cardiomyopathy, Dilated
|
0.020 |
GeneticVariation
|
group |
BEFREE |
To determine whether genetic variants exist in human Hsp20, which may modify these beneficial effects, we sequenced the coding region of the Hsp20 gene in 1347 patients suffering from dilated cardiomyopathy and 744 subjects with no heart disease.
|
18790732 |
2008 |
|
Cardiomyopathies
|
0.020 |
GeneticVariation
|
group |
BEFREE |
In this study, we investigated the functional significance of a novel human Hsp20 mutation (S10F) in peripartum cardiomyopathy.
|
29761889 |
2018 |
|
Cardiomyopathies
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, Ser10 appears to be crucial for the protective effects of HSPB6 and transversion of this amino acid to Phe contributes to cardiomyopathy.
|
29157081 |
2018 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
However, the function of HSP20 in cancer development is not yet fully understood.
|
25187324 |
2015 |
|
Cognition Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, reducing hippocampal and cortical expression of HSP20 with an intracerebral injection of pSUPER hsp20 small interfering RNA significantly diminished the PE-induced overexpression of hippocampal and cortical BDNF and the TrkB ratio and also reversed the beneficial effect of PE in reducing neurotrauma and the cognitive deficits.
|
29574629 |
2018 |
|
Herpes Simplex Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Generally, Hsp20 was identified as a novel anti-HCV, anti-HSV and anti-HIV agent, but Hsp27 was efficient in the suppression of HSV infection.
|
31362669 |
2019 |
|
Parasitic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
A heat shock protein (HSP20) may take part in the physiological response to BPH infestation, making it a potential target for marker-assisted selection (MAS) of rice.
|
30658570 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
However, the function of HSP20 in cancer development is not yet fully understood.
|
25187324 |
2015 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Phospho-mimic-HSP20 overexpression reduced the migration and invasion compared with unphosphorylated HSP20 overexpression.
|
27046040 |
2016 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
With regard to hepatocellular carcinoma (HCC) cells, we previously reported that phosphorylated HSP20 plays a suppressive role in transforming growth factor (TGF)-α-induced cell migration and invasion.
|
28456666 |
2017 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Together, all this data support a role for Hsp20 in parasite invasion and gliding motility.
|
22902747 |
2012 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Accumulating evidence showed that heat shock protein 20 (HSP20) is closely associated with the proliferation, apoptosis, and metastasis of tumor cells.
|
30305007 |
2019 |
|
Sore to touch
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
HSP20, ENO3, and MyHC-I as three muscle protein biomarkers and dry matter intake (DMI) as a rearing factor were involved in three models to explain beef tenderness.
|
30512949 |
2018 |
|
Recurrent tumor
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, immunohistochemical analysis of 94 CRC specimens for HSP20 protein showed that reduced HSP20 expression was related to advanced TNM stage, lymph node metastasis, and tumor recurrence.
|
25187324 |
2015 |
|
Epileptic Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Overexpressed HspB6 Underlines a Novel Inhibitory Role in Kainic Acid-Induced Epileptic Seizure in Rats by Activating the cAMP-PKA Pathway.
|
30511325 |
2019 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Heat shock protein 20 (HSPB6) regulates TNF-α-induced intracellular signaling pathway in human hepatocellular carcinoma cells.
|
25447820 |
2015 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
With regard to hepatocellular carcinoma (HCC) cells, we previously reported that phosphorylated HSP20 plays a suppressive role in transforming growth factor (TGF)-α-induced cell migration and invasion.
|
28456666 |
2017 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
These findings strongly suggest that HSP20 directly associates with PI3K and suppresses its activity in HCC, resulting in the inhibition of the AKT pathway, and subsequently decreasing the growth of HCC.
|
24223153 |
2013 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the clinicopathological and immunohistochemical (including VEGF, Akt, HSP70, and HSP20 expression) factors that affect the overall and disease-free survival of HCC patients following surgical resection.
|
29318189 |
2017 |